Affilliation: National Engineering Laboratory for Neuromodulation, Tsinghua University, China
Biography: Dr. Luming Li, Cheung Kong Scholars Professor
He has received a B.S. degree in Mechanical Engineering (1991) and M.S. and Ph.D. degrees in Material Science and Engineering (1996) from Tsinghua University, Beijing.
As a leader of a multi-disciplinary group, he has designed and created a novel deep brain stimulation device in China for patients in developing countries. To date, the Chinese DBS system, which mediates Variable Frequency Stimulation (VFS), a uniquely different function to commonly used High Frequency Stimulation (FFS), has recently been approved and certificated by the Chinese FDA (2013) following nearly ten years of R&D.
Dr. Li has also designed and created the first implantable, rechargeable neuromodulation device in China, which was certificated in July 2014. These devices are now used in more than 110 clinical centers in China, with more than 2000 successful implantations in patients. Recently, Dr. Li also led his group in the development of the lightest Vagus Nerve Stimulator for Intractable Epilepsy treatment. This device was approved and certificated in May, 2016
Dr. Li has previously been awarded with National Science Fund for Distinguished Young Scholars, 2011, "Top Ten Science & Technology Advances of Chinese College, 2012", and the First prize of S&T, Beijing 2015.
Dr. Li is currently the Director of National Engineering Laboratory for Neuromodulation and the vice chairman of Chinese Society of Neuromodulation.
Talk Title: Deep Brain stimulation from clinical to brain research
Deep brain stimulation (DBS) is the only technique that can directly modulate brain activities using electrical stimulation. A vast amount of research has shown that DBS not only causes a direct effect on the target nuclei, but somehow modulates pathological oscillations that reverberate through multiple brain regions. As such, this provides great opportunities for understanding brain activity in human behaviors.
In the last decade, High frequency stimulation (HFS) has been used for the treatment of advanced Parkinson's disease (PD), which was honored by the Lasker Medical Research Award 2014. However, it is known that HFS is unable to alleviate certain symptoms, such as freezing of gait and dysarthria. We have recently found that the combination of different frequencies can successfully treat these unmanageable symptoms, using our newly developed stimulation therapy called 'Various Frequency Stimulation (VFS)'. Several cases will be presented in this talk to show the significant differences of VFS to the currently used HFS.
From HFS to VFS, a small change but a great deal of difference. There is an enormous challenge in understanding how to modulate the brain? One fact remains is that we need tools and technology. Based on many years' experience on developing implantable devices, we have established a new platform that not only provides DBS therapy but also gives concurrent measurements of local field potential signals to investigate neural circuits. This research tool is like an implanted brain recorder that may allow us to answer vital questions related with various brain disorders and different brain states in combination with behavioral evaluations. In addition, this device also has great potential for providing high clinical value, such as guiding DBS parameter programming, and finally realizing the individualized therapy in closed-loop DBS.
An important issue in DBS neurosurgery is MRI compatibility, which not only relates to clinical practice but also brain research. During MRI scanning, the biggest challenge for the DBS practitioner is the temperature increase caused by RF fields. Several known factors including electrode, extent and device will affect the temperature. Following numerous simulations and experiments, an updated device which could be compatible with 3T MRI has been implemented into the clinic in China.