Affilliation: Bioengineering Department, University of California at Los Angeles
Wentai Liu received B.S. degree from National Chiao-Tung University in Taiwan, M.S. degree from National Taiwan University, and Ph.D. from the University of Michigan. In 1983, he joined North Carolina State University, where he held the Alcoa Chair Professorship in electrical and computer engineering and was the founder of the Analog/Mixed-Mode Design Consortium. In 2003-2011, he was a professor in the electrical engineering at the University of California, Santa Cruz, where he was also the Campus Director of the NSF Engineering Research Center on Biomimetic Microelectronic Systems. Currently he is a Distinguished Professor at both the Bioengineering Department and Department of Electrical Engineering and Director of Chan Soon-Shiong Bionic Engineering Center at California NanoSystem Institute, University of California at Los Angeles. He has been focusing on developing the enabling technology for the main aims at – 1) regaining eyesight for the blind with high visual acuity; 2) restoring motor function for the paralysis; 3) recovering cognition for the cognition impaired; 4) developing state of art neural interface technology. Since its early stages of retinal prosthesis, he has been leading the engineering efforts of the retinal prosthesis to restore vision, leading to successful implant tests in blind patients. The venture finally leaded to successful commercial implants (code name as Argus-II) for blind patients, receiving both CE Mark in 2011 and USA FDA market approval in Feb 2013. He has published more than 300 technical papers and is a co-author of Wave Pipelining: Theory and CMOS Implementation (Kluwer Academic). He received 2009 R&D-100 Editor Choice Award, 2010 Popular Mechanics Breakthrough Invention Award, Outstanding Paper Awards from IEEE-CVPR (1986) and ACCV (2009) Conferences, Alcoa Foundation’s Distinguished Engineering Research Award, NASA Group Achievement Award, and both Outstanding Alumni Award and Honorary Doctorate Degree from National Chiao-Tung University, Taiwan. He has served as guest editors for IEEE proceeding, IEEE Trans. on MTT, and IEEE JSCC. He is currently an Associate Editor for IEEE Trans. on Bio-Circuits and Systems and IEEE Trans. on Biomedical engineering. He was an ISSCC Subcommittee member and a co-founder of the International Conference on Neuroprosthetic Devices (ICNPD).
Talk Title: Epidural neural implant for motor function recovery after spinal cord injury
Recently epidural spinal stimulation has shown effectiveness in recovering the motor function of spinal cord transected mammalian by modulating neural networks residing in lumbosacral spinal segments. Physiology study has shown that the spinal network is capable of performing rapid ongoing motor processing of complex proprioceptive and cutaneous inputs during coordinated motor behaviors such as standing and stepping at the absence of brain input. This offers an opportunity of enabling/recovering the motor function of the paralyzed after spinal cord injury even the signal from the brain is absent. Nonetheless, the clinical application is limited due to lacking of miniaturized and integrated neural implant capable of supporting the optimal stimulation parameters and sites, as well as adaptively adjusting stimulation patterns at run time in response to the subject’s varying physiological states. This talk will present a SoC-based implant and it’s in vivo demonstration for motor function recovery. The SoC integrates together of multi-channel stimulators and recordings, inductive power telemetry, and bi-directional data telemetry.